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KMID : 0616120230540010016
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 1 p.16 ~ p.20
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Structure Elucidation and Antibacterial Activity of Oxazolomycin Family KSM-2690 B Derived from Actinomycete Collected in Jeju Island
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Jeong Hyeong-Ju
Kim Joo-Young
Um Soo-Hyun
Moon Kyu-Ho
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Abstract
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KSM-2690 B (1), a peptide-polyketide hybrid compound, was discovered from an actinomycete strain (CJD 1) isolated from Dong-Baek hill on Jeju Island, Republic of Korea. The chemical structure of 1 was identified by using NMR, MS, and UV spectroscopic analyses. Careful analysis of 1D and 2D NMR data revealed that KSM-2690 (1) has an oxazole ring, a β-lactone-γ-lactam spirocycle ring, and both triene and diene structures. KSM-2690 B (1) showed inhibitory activities against E. coli at 200 μg/mL.
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KEYWORD
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Actinomycete, Secondary metabolite, KSM-2690 B, Oxazolomycin family, Jeju Island
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